Optimised Synthesis of the Bacterial Magic Spot (p)ppGpp Chemosensor PyDPA
نویسندگان
چکیده
منابع مشابه
comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولThe effect of trimethoprim on macromolecular synthesis in Escherichia coli. Regulation of ribonucleic acid synthesis by 'Magic Spot' nucleotides.
During the inhibition of RC(str), but not RC(rel) mutants of Escherichia coli by trimethoprim the unusual nucleotides MSI (guanosine tetraphosphate, ppGpp) and MSII rapidly accumulated. The production of these nucleotides was not dependent on the addition of nucleotide base supplements to RC(str) cultures before trimethoprim, and the MSI nucleotide concentrations in non-supplemented or purine-s...
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چکیده ندارد.
Isolation and Properties of a Ribosome-bound Factor Required for ppGpp and pppGpp Synthesis
A scheme for isolating the stringent factor, a factor which stimulates the pyrophosphorylation of GTP and GDP, from high salt extracts of ribosomes derived from stringent strains of Escherichia coli is reported. The stringent factor was purified 400-fold from the high salt-ribosome eluates. The final preparation was judged to be 85% homogeneous by sedimentation and electrophoretic criteria. The...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2019
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.201900013